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Description
As MTX tends to accumulate in the extravascular compartment, patients with pleural effusion, ascites, and massive edema should get extra caution, due to the risk of toxicity from reabsorption of extravascular fluid [101]
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Zhou and Q

During hunger, ghrelin levels in circulation are increased and activate hypothalamic ghrelin receptor to initiate appetite

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Vitamin B12 absorption decreases because the medication reduces stomach acid production, which is needed to release B12 from protein
