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Although the rapamycin-FKB12 complex does not bind directly to mTORC2, it has been reported that long-term incubation with rapamycin can decrease mTORC2 activity (reviewed in ref

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doi: 10.1016/j.patbio.2009.09.014 6

It comprises the periplasmic copper sensor CopS and the cognate transcriptional regulator CopR (Novoa-Aponte et al
