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One function of HSCs is the production of ECMs, including laminins

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Abstract Immune-mediated inflammatory diseases, such as rheumatoid arthritis, psoriatic arthritis, peripheral and/or axial spondyloarthritis, Crohns disease, and ulcerative colitis, are characterized by molecular and cellular changes in the immune system

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In this review, we describe a series of pruritogens and receptors involved in mediating itching in PN, including cytokines, neuropeptides, extracellular matrix proteins, vasculogenic substances, ion channels, and intracellular signaling pathways