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These exposures may cause localized inflammation and the release of reactive oxygen species (ROS) within colorectal tissues, which may be causative or promotive of neoplastic processes

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Something similar happens with ghrelin [170, 187], although the pituitary ghrelin receptor does not decline with aging and the GH response to ghrelin is still seen in the elderly and there is an age-related decline [188]

Orienting the causal relationship between imprecisely measured traits using GWAS summary data

From infection to the microbiome: an evolving role of microbes in schizophrenia

& Jones, D.P