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Increased GH levels then lead to an increase in Insulin-like Growth Factor 1 (IGF-1), a key mediator of growth hormone effects

Epub 2017 Mar 30

It promotes the proliferation of skin cells that are essential for tissue regeneration, such as fibroblasts and keratinocytes

This may happen even without any specific injury

Frequency of Administration: For significant deficiencies, initial injections may be given weekly, while others may only need monthly shots

The 2016 Noh investigation in International Journal of Molecular Sciences documented novel anti-melanogenesis properties of PDRN, identifying inhibition of microphthalmia-associated transcription factor (MITF) as the mechanism by which PDRN reduces melanin synthesis