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Immune System Function: Investigated for its role in enhancing immune responsiveness, particularly in age-related immune decline

(2011) used the histone deacetylase inhibitor depispeptide to reverse DNA hypermethylation and alter the histone modification pattern at GSTP1 promoter, including a reduction of H3K9me2/3 and H3K27me2/3 and an increase of H3K18Ac, thereby inducing GSTP1 mRNA re-expression

USP8 promotes gemcitabine resistance of pancreatic cancer via deubiquitinating and stabilizing Nrf2

doi: 10.1371/journal.ppat.1000758 229 LevitzS

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References Al-Musawi S, Albukhaty S, Al-Karagoly H, Almalki F (2020) Design and synthesis of multi-functional superparamagnetic core-gold shell coated with chitosan and folate nanoparticles for targeted antitumor therapy