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At the level of post-translational modification, the sirtuin SIRT4 ADP-ribosylates and downregulates GDH in beta-pancreatic cells, thereby decreasing insulin secretion in response to amino acids during calorie-sufficient conditions [74]

Ethics declarations Competing interests The use of this technology, particularly the caspase cleavable fusion protein cassette and use of tagged caspase is covered under Indian and US patents

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In this study, hPSC-CMs subjected to space microgravity showed decreased beating rate and abnormal intracellular calcium cycling

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Electron microscopy was used to identify any subcellular changes
