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Phase Ib study design evaluating the safety, pharmacokinetics and pharmacodynamics of selnoflast, A novel NLRP3 inflammasome inhibitor in early-stage PD (P2-11.007)

Moreover, the surface modification of gold nanorods HA-AuNR/M-M2pep with M2-pep fusion peptide in response to MMP2 can release M2-pep in TME with high MMP2 expression and selectively deplete M2-TAMs to improve the immune activity of TME and effectively inhibit tumor growth (16)

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However, it is important to note that high levels of mutant p53 expression, such as R248Q or R280K, do not necessarily indicate high p53 activity

Cancer 109(4):713-7, 2007

In a trial conducted on a small number of subjects with Alzheimers disease, treatment with liraglutide was able to prevent the progressive decline in cerebral glucose uptake that characterizes patients with the disease [24]