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The APP Dutch mouse model, carrying the E693Q mutation (APP751) under the murine Thy1 promoter, exhibited no neurofibrillary tangles (NFTs) or amyloid plaques

Because it binds to the ghrelin receptor the same receptor responsible for hunger signaling, metabolic regulation, and cardiovascular modulation its side effect profile is shaped not only by elevated GH and downstream IGF-1 activity, but also by direct ghrelin receptor agonism across multiple biological systems

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This work is the first attempt to comprehensively characterize thiol-disulfide redox equilibria in terms of the true standard redox potentials, which are in fact pH-independent

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