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High levels of histamine : While histamine per se does not directly lead to more estrogen production, high estrogen encourages mast cells to produce higher levels of histamine while suppressing the DAO enzyme responsible for breaking down histamine, especially when there is low progesterone
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If its from oxidative stress, CBS upregulation, or methyl overload, supplementation could worsen the problem
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Bioorg Med Chem 25:126131 Papp LV, Holmgren A, Khanna KK (2010) Selenium and selenoproteins in health and disease
