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Mechanistically, overexpression of Rpl15 selectively enhances translation of other ribosomal proteins 38

These include obesity, insulin resistance, metabolic syndrome, type 2 diabetes, and cardiovascular disease
Rinninella E, Raoul P, Cintoni M, Franceschi F, Miggiano GAD, Gasbarrini A, et al

[PMC free article] [PubMed] [Google Scholar] 2.Franco R., Schoneveld O.J., Pappa A., Panayiotidis M.I

Patients should also be aware that certain medicationssuch as proton pump inhibitors (PPIs) and metformincan interfere with B12 absorption, though this is less relevant once on injection therapy

Low levels can be measured in a blood test
