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Like POLG mutations, other genetic abnormalities that impair mtDNA replication, including C10orf2 , DGUOK , MPV17 , PEO1 , and SUCLG1 , are part of the hepatocerebral mitochondrial DNA depletion syndromes, which are syndromes that include prominent liver failure (70, 75, 76)

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Serum chromium and gestational diabetes

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It has been reported that the CPT1C isoform is overexpressed in human tumor cells such as neuroblastoma, several sarcomas of soft-tissues and lung, and malignant peripheral nerve sheath tumors (associated with neurofibromatosis type 1) 45

In the late 1990s, researchers began identifying glaucoma gene mutations, including several in a gene that encodes for the protein TIGR found in the trabecular meshwork