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These findings indicate that lipophagy plays an important role in maintaining lipid levels in the liver and provide a basis for us to understand the molecular mechanism of lipid metabolism mediated by lipophagy

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Although the MIRAD trial used a NT-proBNP cut-of previously validated in type 2 diabetes [23], the cut-of is lower than what is currently used in HFpEF and HFrEF trials [32], and the resultant low proportion of diastolic dysfunction may reduce the studys ability to detect a clinically relevant difference given the size and duration of the trial despite using high-dose therapy

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