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BMJ Open 2014

It declines with age, and lower NAD+ is associated with slower metabolism and the changes we lump together as getting older. NNMT, meanwhile, consumes the raw materials your body uses to make NAD+ and in fat tissue, NNMT is often overexpressed, which can drag NAD+ down right where you least want a sluggish metabolism

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By inhibiting NNMT, 5-Amino-1MQ raises intracellular NAD+ and SAM levels, producing downstream effects on fat cell differentiation and metabolic rate

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