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The heteroaryl moiety may be unsubstituted or substituted by one or more groups selected from halogen, haloalkyl, hydroxy, alkoxy, carbonyl, alkylamido, nitro, amino, dialkylamino, carboxy, thio or thioalkyl

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This dissociation releases the inhibitory effect of GATOR1, facilitanting mTORC1 activation (Gu et al., 2017)

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