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elegans or rodent lifespan by 1825%, increasing antioxidant-enzyme activity by 4045%, and reducing lipid peroxidation by 3040% [32,62,123]
[DOI] [PMC free article] [PubMed] [Google Scholar] 128.Ceriello A
In a related study, when C57BL/6J mice, rendered diabetic by STZ, were treated for 8 weeks with GABA (250g/kg), blood glucose concentrations declined in concert with a ~3-fold increase in plasma insulin, yet plasma glucagon was unaltered
doi: 10.3390/medicina45020012 254 FernstromMHKupferDJ
7b) and a trend toward decreased IRS-1 and Akt phosphorylation (Fig
Nutrients 11, 1135
