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ACTIVE INGREDIENT

Suggested use: As a dietary supplement, 1 tablet daily on an empty stomach, or as directed by a healthcare professional

Nat Chem Biol (2017) 13(1):918

doi: 10.1038/s41598-018-21463-1 114 SedighANordlingSCarlssonFLarssonENorlinBLbenowNet al

Clinical translation of the developed PLGA-based nanosystems encapsulating conventional drugs and/or bioactive phytochemicals remains a challenge due to limited clinical trials validating the safety and efficacy of PLGA nano-systems

A systematic review by researchers at the University of Copenhagen cited an average of 15% bioavailability from oral melatonin, which was highly variable (range: 933%) and affected by age, illness, caffeine, smoking, and medications [296]