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The most common symptoms patients experience are chronic pruritus and eczematous lesions, which can adversely impact the quality of life for individuals afflicted by this disease [84]

After adjusting for sex and health status, age-dependent changes remained highly significant in the N/NS pathway control ratio (slope = 0.0007, SD 0.0002, P = 0.0002) and the S/NS pathway control ratio for PBMCs (slope = 0.0010, SD 0.0002, P = 80 years)

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