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Description
It operates by elevating low levels of the amino acid carnitine to reduce symptoms associated with this condition such as anemia, muscle deterioration, or heart failure

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For example, in human fibroblasts undergoing senescence induced by transient activation of p53 with Nutlin3a, lysosomal damage led to H + overflow, inducing more intracellular acidosis than in uninduced cells

CoelhoI C F, MotaI J F, BragranaI E, BuriniI R C

(2006) (Fig

Considering active targeting mechanisms, there are plenty of works describing the modification of IONPs with targeted molecules to facilitate their transport to the brain tumor [321]
