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This can directly verify the central retinal artery affected by L-NAME (i.e., vasoconstriction), with adequate time to produce/initiate the chain of damaging events, further lesion progress, and progressive NO-system failure from week 1 to week 2 to week 4 in L-NAME-treated rats [13]

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10.1038/s41598-023-29546-4 151 WeaverC

Although it has been known both in humans and rats that mucosal GSH becomes depleted in colitis (Buffinton et al, 1995

Seddiki N, Santer-Nanan B, Tangye SG, et al