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Mutations in the mitochondrial Fe-S cluster biosynthesis or relay machineries have been shown to dramatically blunt respiration in multiple model systems, most notably affecting complex I and II stability

Moreover, in conditions not directly caused by flavoprotein gene mutationssuch as L-2-hydroxyglutaric aciduria (L2HGA) or Friedreichs ataxia (FRDA)metabolic pathology often involves secondary dysfunction of FAD-dependent enzymes and redox disruption

and Kaplowitz, N

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By approaching your research with this level of diligence, you empower yourself to generate data that is not only valid but also has the potential to contribute to the ever-growing understanding of human recovery and regeneration