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In the cell, 90% of GSH is located in the cytoplasm, 1012% in the mitochondria, and a small percentage in the endoplasmic reticulum (ER) ( The -glutamatyl cycle or Meister cycle initially proposed in the 60s described the synthesis and breakdown of GSH, making it a strong cysteine donor in physiological and pathological conditions ( de novo synthesis of GSH by cancer cells occurs as follows: GSH is first exported from the cell of origin via transporters known as Multiresistance Drug Proteins (MRPs), which belongs to the ATP binding cassette (ABC)s transporter family and is well-known player in cancer resistance mechanisms ( via the proton-coupled oligopeptide transporter family member PEPT2 (35, 36) or further cleaved by dipeptidases to cysteine and glycine

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Clinical applications of growth factors in bone injuries: experience with BMPs

10.1007/s11154-017-9424-1 Rev Endocr Metab Disord

ROS-mediated PERK-CHOP pathway plays an important role in cadmium-induced HepG2 cells apoptosis