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BPC-157 is synthesized using solid-phase peptide synthesis (SPPS) and purified via high-performance liquid chromatography (HPLC) to achieve analytical research standards

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A decrease in vitamin B12 and/or folate results in an increase in homocysteine level

PMID: 36917261

First-line pharmacologic options (evidence-based): Gabapentin/pregabalin , tricyclic antidepressants (e.g., amitriptyline/nortriptyline), and topical 5% lidocaine patches