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The most compelling candidates address multiple mechanisms simultaneously, which is why they show stronger results than compounds targeting a single pathway

Patients should be counseled that identifying an effective pain relief regimen may require multiple trials of different medications in order to identify the medication(s) that produce optimal effects for that particular patient

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However, this is the first demonstration of a human serum-derived educated spheroid system being used to prospectively confirm its predictive accuracy, which strengthens our confidence in its robustness