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Independently of PKC activation, an increase in intracellular calcium levels can also lead to negative c-MET regulation [Gandino et al

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Neurotoxicity ) of the Prescribing Information (PI) for Sabril (vigabatrin): "Intramyelinic edema (IME) has been reported in postmortem examination of infants being treated for IS with vigabatrin. See details in the FDA letter of approval and the updated PI