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To measure GSSG specifically, researchers first derivatize free GSH using 2-vinylpyridine (2-VP) or N-ethylmaleimide (NEM)

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doi: 10.1021/jm00396a012

The study found that this pathway begins with the activation of c-Jun-N-terminal kinase 1 (JNK1) and increased receptor-interacting protein 1 levels (RIP-1)

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