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Description

These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks

Supply shortages have been a recurring issue since the compound gained popularity, though manufacturing has been scaling to meet demand

Just slight changes in the level (too high or too low) can be dangerous or even life-threatening

doi: 10.1056/NEJM197706232962502 25 SonKBLeeTJHwangSS

NaBPC157 consistently reduced the otherwise prominent lesions in the stomach of the control rats, as well as the lesions in the small intestine in the indomethacin groups