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Sublingual delivery can in principle bypass first-pass hepatic metabolism by absorbing through the oral mucosa directly into systemic circulation

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G.VastradA

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Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

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In one study, Wedenoja et al

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doi: 10.3389/fphar.2020.00557 95 KhanSKhanSALuoXFattahFJSaltarskiJGloria-McCutchenYet al

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The use of patented methods such as "Anti-fragile" (gentle vacuum stabilisation) and lipid encapsulation helps preserve the bioactivity of the ingredients without the need for synthetic preservatives

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