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The recommended daily dose must not be exceeded

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Use each injection site only once per week, giving the area time to recover between injections

This was further validated by studying the phosphorylation of the Thr451 residue on PKR subsequent to 4CBA treatment in murine brown adipocytes which was increased after 24 h of treatment (Figure EV3B)

These drugs should be started at a low dose, with gradual titration up to a maximum daily dose of 3600 mg for gabapentin (1200 mg thrice a day) and 300 mg for pregabalin (dosed twice a day or thrice a day)

Hepatology 45 , 879885 (2007)