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This means they can't absorb B12 from food, though they can from a supplement

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We exploited the secured C-terminal modification site of each peptide, as discussed above, and prepared fluorescently labelled macrocycles aML5-Fluo, aMD4-Fluo and aMD5-Fluo via the -amino group of a lysine residue in a tag peptide at the C-terminus (Supplementary Table 2 and Supplementary Fig

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5), measures these pharmacophoric features over total compounds, determining hydrogen-bond acceptors, hydrophobic centers, and aromatic rings as key drivers of dual-target activity