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Animal studies demonstrate that severe vitamin A deficiency or excess during critical periods of development results in a spectrum of malformations, especially affecting craniofacial structures, limbs, and visceral organs (65)

Bescos R, Ashworth A, Cutler C, et al

Metabolically distinct weight loss by 10,12 CLA and caloric restriction highlight the importance of subcutaneous white adipose tissue for glucose homeostasis in mice

[DOI] [PubMed] [Google Scholar] 35.Zhou S, Xue J, Shan J, Hong Y, Zhu W, Nie Z, Zhang Y, Ji N, Luo X, Ma W

However, specific subclasses demonstrate particularly potent effects

However, it is well recognized that sarcopenia is accelerated by the lack of physical activity, alterations in metabolism, neuromuscular deterioration, and marginal nutrient intake and absorption [6]