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S12), it was found that the combination of Zn 2+ , Cu 2+ and Qu (ZCQ) caused changes in more than 30 pathways, including the steroid biosynthesis pathway related to DHT [[48], [49], [50]], the TNF pathway related to inflammation [51], the TGF- pathway related to hair follicle growth cycle [52], the VEGF and HIF-1 pathways related to angiogenesis [53,54], and the AMPK pathway related to skin regeneration [55]

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however, these drugs have been misused Currently available data do not suggest that rhGH treatment should be used to promote longevity Lack of GH action in mouse models is associated with extended longevity, but the mechanism underlying the increased lifespan has yet to be established Given the effects of reduced GH/IGF-1 signalling on lifespan in rodents, decreased GH action might be beneficial for humans, but clinical trials are needed to assess long-term outcome of GH/IGF-1 inhibition This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access 189,00 per year only 15,75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF