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10.1038/s41398-018-0353-x [DOI] [PMC free article] [PubMed] [Google Scholar] 72.Cao B, Jin M, Brietzke E, Mcintyre R, Wang D, Rosenblat J, et al
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Research has demonstrated that inhibiting ACAT1 activity upregulates plasma membrane cholesterol levels in CD8 + T cells, which results in enhanced T cell receptor clustering and signal transduction, as well as more efficient immunological synapse formation and antitumor response [117]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 130.Mejia EM, Hatch GM
Future clinical trials may explore novel TRPA1-targeted analgesics
