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Another fusion protein targeting PD-L1 and TGF-, SHR1701, is being investigated in a phase II trial in combination with cyclin-dependent kinase 4/6 inhibitor in patients with hormone receptor-positive, HER2-negative, endocrine-resistant advanced breast cancer (NCT04355858)

[DOI] [PubMed] [Google Scholar] 693.SPS3 Investigators, Benavente OR, Hart RG, McClure LA, Szychowski JM, Coffey CS, Pearce LA

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Of course, the best remedy is prevention

It clearly shares some but not all of the biological effects of intact hGH, with its activity appearing to converge on 3-adrenergic receptor-mediated pathways in adipose tissue rather than through the classical GH receptor

However, factors like aging, stress, pollution, and poor diet reduce its levels