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Mild, temporary effects such as fatigue, injection-site irritation, or headache may occur

These observations indicate that the strength of responses of chemotherapy-resistant cancers to anti-IGF agents will depend on the extent of IGF-1R signaling in tumors

Cell Mol Life Sci 57(3):500505 Falco MJC, Pouliquem YBM, Lima MAS, Gramosa NV, Costa-Lotufo LV, Milito GCG et al (2005) Cytotoxic flavonoids from Platymiscium Floribundum

There are six IGFBPs types (containing approximately 200300 AAs) that regulate IGF signaling and prolong its half-life, and they bind more than 90% of IGF-1 present in circulation (about 1% of IGF-1 in circulation are in a free-active form), simultaneously blocking its binding to IR (42, 43)

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Third-Party Tested in the USA