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We showed that mice fed a high-fat diet (HFD) for 12 weeks developed hepatic steatosis and liver injuries, which were associated with not only TNF overproduction but also hepatic glutathione dysregulation, characterized by GSH reduction and GSSG elevation

doi: 10.1001/jama.2021.12531

Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

this palmitoylation decreases during starvation-induced autophagy

Results NPs induced synergistically-enhanced ferroptosis of CAFs In our work, to evaluate the impact of CAFs on CRC patient survival, tumor samples from GSE17538 and GSE87211 were grouped by CAF scores using microenvironment cell populations-counter (MCPcounter), estimating the proportion of immune and cancer cells (EPIC), and estimation of stromal and immune cells in malignant tumor tissues using expression data (ESTIMATE) 30,31,32,33,34