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The dosing schedule began at 14 mg in week 1, followed by 28 mg (week 2), 42 mg (week 3), and 56 mg for five consecutive weekly administrations (week 4, 5, 6, 7, 8)

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However, there is considerable variability in doses and extract preparation, including oil-based formulations, methanol extracts and advanced nanoformulations, which might affect bioavailability and clinical efficacy