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284 Disintegration of glia limitans translates into the widespread damage to the bloodbrain barrier and degranulation of natural killer cells that release perforins and granzyme, which in turn, further injure astrocytes and endothelium

d , FRAP analysis of Halo-RPB1 U2OS cells that were either untreated or treated with UV (8 J/m2, 1 h recovery) or FA (0.3 mM, 1 h)

To evaluate if knockout of ABCC1 also enhances the anti-leukemic effects of AZD-4320 in vivo, we transplanted equal numbers of MOLM-13 AAVS1.1 control or ABCC1 -knockout cells into NSG-S mice and treated them once a week with either AZD-4320 (10 mg/kg) or vehicle

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This prevents excessive scar formation, for a more even, balanced result