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10.1186/s12935-021-02366-0 339 NieuwkampD

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We monitored the response of NAPstar3, NAPstarC, and PeredoxDS probes expressed in wild-type cells, in cells deleted for the GLR1 gene (encoding glutathione reductase), and in cells deleted for TRX1 and TRX2 (encoding the two cytosolic thioredoxins)

The Nrf2/ARE signaling pathway is inhibited by elevated expression of Smurf1 in DKD, which raises ROS levels in GMCs and promotes renal fibrosis[47]

This research-focused combination groups three compounds commonly referenced in experimental studies examining cellular and molecular pathways within controlled laboratory environments