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Description
Hypersensitivity may occur as a result of unmasking of receptors or accentuation of signal amplification

Lett., 2007, 413 (1), 7781

Gullberg, R.G

Fumarate and succinate regulate expression of hypoxia-inducible genes via TET enzymes

Beyond specific infections, a generally proinflammatory state, characterized by elevated circulating levels of cytokines like TNF, IL1, and IL6, can sensitize nociceptors, promote neuroinflammation via glial cell activation in the CNS, and drive central sensitization, thereby lowering pain thresholds and facilitating chronicity across various pain conditions

Berberine can arrest the cell cycle of lymphocytic Jurkat cells at G0/G1 phase, suggesting that it may play a positive role in the treatment of leukemia [235]
