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12, 14, 15, 16 BSO enhanced L-PAM activity in the RPMI-8226/LR-5 and RPMI-8226/S MM cell lines, 8 and in the MOPC-315 murine plasmacytoma

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This methionine-dependent activation of TORC1 increases overall translation capacity (through increased ribosome synthesis, which is the canonical output of TORC1 activity)

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doi: 10.1001/jama.2018.19283 [PubMed] 30916014 Savic LC, Khan DA, Kopac P, Clarke RC, Cooke PJ, Dewachter P, Ebo DG, Garcez T, Garvey LH, Guttormsen AB, Hopkins PM, Hepner DL, Kolawole H, Krigaard M, Laguna JJ, Marshall SD, Mertes PM, Platt PR, Rose MA, Sabato V, Sadleir PHM, Savic S, Takazawa T, Voltolini S, Volcheck GW

6 Scientists continue to study the potential of L-glutamine to prevent or treat certain conditions