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Consistent with earlier reports (Han et al., 2013), analysis of the glutathione-deficient pad2-1 plants demonstrated that 30% of the wild-type glutathione level is enough to sustain ascorbate recycling during high-light exposure

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Tamoxifen treatment caused a significant reduction in the expression of Trp53 in adipocytes isolated from eWAT, sWAT, and in bulk BAT of CreERT2-positive mice, whereas the expression of Trp53 in liver and skeletal muscle remained unaltered (Supplementary Fig

This response may be part of an emergency response with the sudden onslaught of oxidants from the CS exposure or it may be the depletion of GSH during the CS exposure combined with the increase in oxidants from CS that acts as a trigger to initiate this response