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This pathway plays a vital role in maintaining cellular homeostasis, particularly in the heart, where protein misfolding and aggregation can have severe consequences for cardiac function

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During an in vivo investigation involving transgenic APP/PS-1 mice, the oral administration of NAC through drinking water prior to the development of the disease demonstrated the ability to reduce oxidative damage in neurons (174)

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The model could be relevant to address limitations of conventional animal models and could prove useful to detect undesirable drug adverse events to avoid unnecessary animal suffering during preclinical testing