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Therefore, the drugs capable of effectively imitating the substrates of influx transport would have higher probability of crossing the BBB [162]

Many studies have shown that the activity of PRMTs is related to cancer stem cells (CSCs), which can self-renew and generate differentiated progeny

However, the exact molecular target of natural products remained unclear

Several studies have revealed that the gene encoding 3-phosphoglycerate dehydrogenase, the rate-limiting serine biosynthesis enzyme, is amplified in breast cancers and melanomas [25,26]
