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Preclinically, these inhibitors reduce infarct volumes and improve functional recovery, not merely by lowering lactate but by reprogramming cellular metabolism: forcing neurons to resurrect oxidative phosphorylation in salvageable penumbral regions and redirecting glucose toward the PPP to bolster NADPH-dependent antioxidant defenses [208, 209]

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The rhythmic control of pyruvate dehydrogenase activity by brain and muscle ARNT-like 1 (BMAL1) indicates that a CCR2 antagonist administered at dawn may reduce neuroinflammation, while the same drug given at dusk could worsen it

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Plaque rupture leads to formation of a blood clot that can block blood flow or break off into circulation and obstruct smaller vessels, sometimes resulting in major, life-threatening, catastrophic cardiovascular events

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Int J Curr Res Acad Rev

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