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Description
The sequence of primers used for mutagenesis were (5-CATTCTGGCC GAA AGCCCGGAACTGTATAGTAGC-3) and (5-GTTCCGGGCT TTC GGCCAGAATGCGGCCCACAAAATC-3) for MhTyrA and (5-GTAAC AAT CCACTTCAGCTGTTTATAGACTTGCAAC-3) and (5-CTGAAGTGG ATT GTTACACGTTTGTTCGCGCACCTG-3) for SsTyrA (mutated codons are italicized)
Trial SURPASS-1 (Lancet 2021) Population 478 adults with T2D, monotherapy vs placebo
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25 In the early 1990s, despite John Engs team identifying a potential diabetes treatment in exendin-4, it initially lacked attention and funding for development
In addition, they also showed a significant increase in tubular cells positive for FOXO4 foci (Fig
