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( h ) Cells were treated with succinate and olaparib or cisplatin alone or in combination with or without l-carnitine supplementation (n = 4 technical replicates representative from 2 independent experiments)

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10.1093/omcr/omab121 Uyioghosa Asemota, Sheldon Greenberg, Amit Gulati, Kamlesh Kumar, Kalyana Janga

These cytokines can promote cognitive dysfunction as they are able to disrupt the blood-brain barrier (BBB), allowing proinflammatory cytokines (52), cells (such as dendritic, B cells, and T cells) (52), and gut microbes or toxins (355) to translocate into the brain and promote inflammation ( Figure 10 )

doi: 10.1007/BF00687664

Epigenetic Regulation in Neurodegenerative Diseases