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Decades of work on the effects of oxidative stress on lens proteins have built on the seminal work of Antoinette Pirie, 14 , 15 and Ruth van Heyningen 16 , and colleagues, 17 Working at the Nuffield Laboratory of Ophthalmology, Oxford University in the 1960s and 1970s, they demonstrated that exposure of lens protein solutions to sunlight caused the proteins to become heavily pigmented, to cross-link, and to aggregate

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To overcome these limitations, researchers have introduced third-generation hybrid approaches that integrate both knowledge- and data-driven techniques

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