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Nevertheless, studies utilizing more specific biomarkers of vitamin B 12 status, including measures of holo-transcobalamin and methylmalonic acid, have shown more consistent results and a trend towards associations between poor vitamin B 12 status and faster cognitive decline and increased risk of Alzheimers disease (82-86)

While the anti-aging implications have not been studied directly in humans, the mechanistic pathway is well-established and suggests potential benefits for anti-aging applications

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Moreover, some inflammatory cytokines are known to reduce IGF-1 levels in animal models [215]