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For instance, building upon the established role of GPX4 in suppressing ferroptosis in alveolar cells, the demonstrated therapeutic potential of mesenchymal stem cell-derived exosomes, the feasibility of CD44-mediated macrophage targeting, and the precedent for pulmonary nucleic acid delivery, the engineering of inhaled exosomes to deliver GPX4 mRNA specifically to alveolar macrophages represents a promising frontier (175, 178)

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Moreover, lactate-mediated H3K18 lactylation positively regulates the transcription of tumor necrosis factor superfamily member 9 (TNFSF9), further linking lactate metabolism with M2 polarization events [171]

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Human testis expresses STS and efflux transporters and uptake membrane carriers for sulfated steroids 74

PMID 11665618